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ED protocol

Ad ID: 84349 September 17, 2015 16 views

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LONDON — Joseph S. Alpert, MD, professor of medicine at the University of Arizona College of Medicine, Editor-in-Chief of the American Journal of Medicine and Cardiology Today Editorial Board member, provides perspective on a European Society of Cardiology Congress Hot Line trial presentation by Dirk Westermann, MD, PhD, on protocols involving high-sensitivity troponin assays that can be used to rapidly rule out MI in patients presenting with chest pain.

Such assays are not yet approved in the United States, but are available in much of the rest of the world; they are as much as 20-fold more sensitive than the assays currently available in the United States, Alpert said.

Alpert noted that most patients who show up in the ED with chest pain don’t actually have MI. However, acute ischemic heart disease is a “life-threatening condition on the long list of [causes for] chest discomfort,” so it is important to determine quickly whether the pain is due to MI.

In the study by Westermann and colleagues, patients received a troponin assay at 1 hour and at 3 hours, and, unexpectedly, the results at 1 hour were more accurate than the results at 3 hours, Alpert said. At 1 hour, the algorithm had a 99.7% negative predictive value and 50% of patients were sent home immediately, with others admitted to the coronary care unit or kept for observation, Alpert said.

“I’m sure we’ll be seeing these protocols a lot in the United States once we have high-sensitivity troponin [assays available], and many of us think that will be in the very near future,” Alpert concluded.
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